Structure-Guided Adaptive Propagation for Protein-Protein Interaction Site Prediction

Accurate prediction of protein-protein interaction sites (PPIS) is essential for understanding cellular processes, disease mechanisms, and therapeutic target discovery. Graph-based deep learning has advanced PPIS prediction by incorporating residue-level structural context. However, most graph-based models still rely on fixed propagation schemes that treat all residues similarly, despite the structural and functional heterogeneity of protein interfaces. Such propagation may limit the ability to adapt information diffusion to local geometric environments, making it difficult to distinguish true interaction sites from structurally similar non-interacting neighbors. We present SGAP-PPIS, a structure-guided adaptive propagation model for PPIS prediction. Rather than using a fixed propagation mechanism, SGAP-PPIS leverages multi-scale geometric states from an equivariant graph neural network to generate residue-wise propagation coefficients. This design allows each residue to adaptively balance local feature preservation and neighborhood diffusion according to its geometric microenvironment. Experimental results show that SGAP-PPIS achieves competitive performance among the state-of-the-art methods on Test\_60. Ablation studies show that geometry-conditioned adaptive propagation, scale-aligned geometric guidance, and multi-step propagation-state representation jointly drive these improvements.

Temporally-Aligned Evaluation for Audio-Driven Talking Head Generation

Audio-driven talking-head generation has advanced rapidly, yet existing evaluation protocols mainly rely on frame-wise metrics that assume strict temporal correspondence between generated and reference videos. This assumption does not match speech-driven facial motion, which naturally includes slight timing shifts, different speaking speeds, and stylistic variations. As a result, conventional metrics may treat harmless timing differences as quality errors, making it harder to fairly compare methods and understand their trade-offs. In this work, we argue that evaluation of dynamic generative models should be formulated as a sequence-alignment problem rather than independent frame comparison. We introduce a unified sequence-level reformulation that integrates Soft Dynamic Time Warping into established evaluation pipelines. By aligning feature trajectories while preserving temporal order, the proposed framework provides robustness to bounded temporal misalignments without altering the underlying perceptual, identity, or synchronization encoders. We show that frame-wise evaluation can be viewed as a special case under rigid alignment, while sequence-level alignment provides improved stability, lower sensitivity to timing differences, and clearer separation between modeling paradigms. Building on this principled formulation, we conduct a large-scale benchmark of 20 methods across seven datasets spanning canonical, in-the-wild, and style-diverse scenarios under standardized protocols. Extensive experiments show that temporally aligned metrics are more robust to timing differences, provide more consistent results across datasets, and better reveal systematic trade-offs between modeling paradigms, such as synchronization versus realism and expressiveness versus stability.

UME: A Unified Meta-Generalization Framework for Cross-Domain ETA

Accurate Estimated Time of Arrival (ETA) prediction on checkout page is crucial in instant logistics for enhancing user satisfaction, optimizing dispatching, and controlling operational costs. In international on-demand delivery platforms, where ETA data originates from diverse countries or regions with different patterns, multi-domain modeling is of great importance and has been widely adopted. However, existing methods still face three critical challenges in real-world deployment. First, current multi-domain models struggle to generalize to completely unseen domains, failing to achieve zero-shot prediction during the initial cold-start phase. Second, cross-domain feature spaces are often assumed to be consistent, whereas new domains commonly suffer from structural missingness of offline (statistical) features due to the lack of historical data. Third, such feature missingness often compels industrial systems to model mature and cold-start domains separately, hindering knowledge transfer and increasing maintenance overhead. To address these challenges, we propose \textbf{UME}, a \textbf{U}nified \textbf{M}eta-generalization framework for \textbf{E}TA. Specifically, UME integrates a unified dual-branch architecture with a novel meta-learning mechanism that employs a hypernetwork-based meta learner. By leveraging domain-level knowledge and instance-level context, the meta learner empowers three meta modules to dynamically modulate feature gating, expert attention, and final prediction, capturing cross-domain correlations and facilitating intra-domain adaptation. A knowledge distillation strategy is further introduce to enhance performance. UME has now been deployed in Meituan-keeta delivery platform (the largest international food delivery platform in China). Extensive offline experiments and online A/B tests demonstrate that UME significantly outperforms existing baselines.

Semi-Supervised Noise Adaptation: Transferring Knowledge from Noise Domain

Transfer learning aims to facilitate the learning of a target domain by transferring knowledge from a source domain. The source domain typically contains semantically meaningful samples (*e.g.*, images) to facilitate effective knowledge transfer. However, a recent study observes that the noise domain constructed from simple distributions (*e.g.*, Gaussian distributions) can serve as a surrogate source domain in the semi-supervised setting, where only a small proportion of target samples are labeled while most remain unlabeled. Based on this surprising observation, we formulate a novel problem termed *Semi-Supervised Noise Adaptation* (SSNA), which aims to leverage a synthetic noise domain to improve the generalization of the target domain. To address this problem, we first establish a generalization bound characterizing the effect of the noise domain on generalization, based on which we propose a Noise Adaptation Framework (NAF). Extensive experiments demonstrate that NAF effectively leverages the noise domain to tighten the generalization bound of the target domain, leading to improved performance. The codes are available at https://github.com/AIResearch-Group/SSNA.

SwanVoice: Expressive Long-Form Zero-Shot Speech Synthesis for Both Monologue and Dialogue

Zero-shot text-to-speech (TTS) has improved substantially for single-speaker synthesis, yet expressive long-form multi-speaker dialogue remains difficult. A common workaround is to synthesize each turn with a monologue TTS model and stitch the outputs together. This adds inference cost and often breaks acoustic consistency, conversational coherence, and affective continuity across turns. Recent dialogue TTS systems have begun to address this setting, but they still struggle to keep expressive coherence, controllable speaker switching, and monologue quality at the same time. We present SwanData-Speech and SwanVoice. SwanData-Speech builds monologue and dialogue corpora from in-the-wild audio, using Swan Forced Aligner for pause-aware word-level alignment and RobustMegaTTS3 for pronunciation-hard cases. Built on these data, SwanVoice is a zero-shot TTS model for 1--4 speakers, combining a 25 Hz VAE, raw-text conditioning with pause-aware symbols and pinyin substitution, and a flow-matching DiT with speaker-turn conditioning. Training starts from monologue speech, moves through mixed and real dialogue data, and then uses DiffusionNFT post-training with phone-level and speaker-similarity rewards. On SwanBench-Speech, SwanVoice obtains higher richness and hierarchy scores than all evaluated open-source baselines in both monologue and dialogue settings, while content accuracy remains the main limitation. Audio demos are available at https://swanaigc.github.io//#swanvoice.

Towards Streaming Synchronized Spatial Audio Generation via Autoregressive Diffusion Transformer

Real-time and accurate spatial audio generation is pivotal for delivering an immersive experience. However, existing spatial audio synthesis technologies are often encumbered by a tradeoff between generation quality and high inference latency, as well as difficulty in capturing precise spatial information from multimodal inputs. To address these challenges, we propose SwanSphere, a unified streaming framework for high-fidelity spatial audio generation from panoramic videos and text prompts. SwanSphere mainly makes the following contributions: 1) We introduce a causal autoregressive diffusion transformer architecture that enables streaming high-quality spatial audio generation. 2) We design a Spatial Video-Audio Contrastive (SVAC) learning strategy to align the video encoder with the acoustic domain, and further employ a multi-objective online direct preference optimization (ODPO) scheme, resulting in strong spatial perception and robust multimodal spatial audio synthesis. 3) To alleviate the current scarcity of spatial audio datasets, we also develop an automated annotation pipeline for generating detailed spatial captions. Experimental results demonstrate that SwanSphere achieves superior performance in both video-to-spatial and text-to-spatial audio generation tasks. Demos can be found at: https://swanaigc.github.io.

Masking Stale Observations Helps Search Agents -- Until It Doesn't: A Regime Map and Its Mechanism

Long-horizon search agents accumulate large amounts of retrieved content across many tool calls, making context-budget efficiency increasingly important. A minimal intervention is to mask stale observations from the context as the trajectory progresses, but it remains unclear when this form of context management helps and why. We study observation masking through a systematic sweep over various agent backbones (4B to 284B parameters) and three retrievers on offline and live-web agentic search benchmarks. We find that the accuracy gain from masking follows an asymmetric inverted-U shape when plotted against the model's accuracy without context management: a plateau under weak retrievers, a peak when a strong retriever meets a mid-capacity model, and a sharp collapse when the model is saturated. This pattern reflects the interaction between retriever recall and the model's implicit filtering capacity, rather than either factor in isolation. Mechanistically, masking implements a token-for-turn trade-off: it removes observations the model has largely stopped attending to and pages the agent rarely re-opens. The added turns help when they convert failures into successes, but they fail when masking removes evidence the model would otherwise have used. We therefore reframe context management as a regime-dependent intervention and provide a holistic perspective for analyzing context use in agentic deep search. We release our scaffold and trajectories here (https://github.com/i-DeepSearch/observation-masking) to support future research.

Column-Wise Analog Processing for Hybrid Precoding in Millimeter Wave Downlink Multi-User Massive MIMO Systems

In millimeter wave (mmWave) massive MIMO systems, existing alternating minimization (AltMin) based hybrid digital-analog precoding algorithms can achieve near-optimal spectral efficiency (SE) of the fully-digital precoding. However, this kind of AltMin algorithms require several hundreds of iterations to optimize the analog precoder, thus increasing the complexity. This paper focuses on reducing complexity of the analog precoding and proposes a column-wise analog precoding (CWAP) algorithm. The main idea is to seek closed-form solution of the analog precoder, through which the analog precoder can be easily computed in one step instead of iterations, thus reducing the complexity. Specifically, by assuming that perfect digital precoder is deployed at the base station (BS) to eliminate interferences among users, we simplify the expression of achievable SE for each user. Subsequently, the simplified SE is further converted to the sum of a series of sub-rates, each of which is related to the corresponding column of the analog precoder. The optimization problem of maximizing the SE is then transformed into a series of sub-problems of maximizing each sub-rate. Upon solving each sub-problem, closed-form solution of each column of the analog precoder can be directly obtained without iterations, resulting in reduced complexity. Simulation results demonstrate that (a) when the number of RF chains equals the number of data streams, the proposed scheme can achieve approximately same sum-rate as the AltMin algorithms; (b) when the number of RF chains is larger than the number of data streams, the proposed scheme can achieve higher sum-rate than the AltMin algorithms; (c) the proposed scheme has lower complexity than the AltMin algorithms (almost one order of magnitude reduction in some cases).

MIMO-OTFS-Based Semantic Communication for High-Mobility Scenarios

In high-mobility scenarios with time-frequency doubly-selective channels, existing semantic communication systems suffer significant performance degradation. To address this issue, we propose a semantic communication framework that synergistically integrates multiple-input multiple-output orthogonal time frequency space (MIMO-OTFS) with semantic-aware sub-channel allocation. First, an entropy module is employed to evaluate importance of different semantic features, and the Kendall correlation coefficient is used to quantify the alignment between semantic importance and sub-channel conditions. Subsequently, joint optimization of the encoder and decoder is achieved through a comprehensive loss function that balances image classification accuracy, reconstruction quality, and sub-channel matching degree. Experimental results confirm the superior reconstruction quality of our proposed framework compared to conventional semantic communication systems based on orthogonal frequency division multiplexing in high-mobility channel environment.

NaRA: Noise-Aware LoRA for Parameter-Efficient Fine-Tuning of Diffusion LLMs

Diffusion Large Language Models (dLLMs) have emerged as a promising non-autoregressive generative paradigm. Given the prohibitive computational cost of full fine-tuning, Parameter-Efficient Fine-Tuning (PEFT) has become the standard approach. However, existing PEFT methods (e.g., LoRA), originally tailored for autoregressive models, rely on static parameters that are agnostic to the noise level. Consequently, they ignore the intrinsic dynamics of the diffusion process, where input distributions and generation difficulty shift significantly along the denoising trajectory, rendering them suboptimal for dLLMs. To address this, we propose Noise-aware Low-Rank Adaptation (NaRA), which introduces a low-rank core matrix generated by a lightweight, globally shared hypernetwork conditioned on the noise level. This design enables the update matrices to vary continuously along the diffusion process while keeping parameter and latency overhead negligible. We provide a theoretical justification for the proposed NaRA framework and empirically demonstrate consistent improvements over noise-agnostic baselines across commonsense reasoning, mathematical reasoning, and code generation benchmarks. Our code is available at https://github.com/generaldi/NaRA.